CENTRO DE QUIMICA INORGANICA "DR. PEDRO J. AYMONINO"
Unidad Ejecutora - UE
Spectroscopic Behavior and SOD-Like Activity of the Copper(II) Complex of Hippuric Acid
MI RODRIGUEZ; MANCA, SG; TOTARO, RM; ENRIQUE JOSE BARAN
Acta Farm. Bonaerense
Colegio de Farmaceuticos de la Prov.de Bs. Aires
Lugar: La Plata; Año: 2006 vol. 25 p. 71 - 71
The dimeric copper(II) complex of hippuric acid (Hhipp), of stoichiometry [Cu2(hipp)4(H2O)4].2H2O has been thoroughly characterized by means of its infrared,Raman and electronic spectra, which could be interpreted on the basis of the known structural data. The superoxide dismutase-like activity of the complex was investigated using the nitrobluetetrazolium/superoxide reduction assay and compared with that obtained for the native Cu2Zn2-SOD enzyme, tested under the same experimental conditions. The results show a very important SOD-like activity, suggesting that these type of complexes may be interesting for the future search of new SOD-mimetic drugs.