Copper Complexes with Heterocyclic Sulfonamides: Synthesis, Spectroscopic Characterization, Microbiological and SOD-Like Activities: Crystal Structure of [Cu(sulfisoxasole)2(H2O)4].2H2O

KREMER, E; G FACCHIN; E.ESTEVEZ; P ALBORES; ENRIQUE JOSE BARAN; J ELLENA; TORRE, MH

Journal of Inorganic Biochemistry

Elsevier

Lugar: Amsterdam, Holanda; Año: 2006 vol. 100 p. 1167 - 1175

0162-0134

 The synthesis, characterization and comparative biological study of series of antibacterial copper(II) complexes with heterocyclic sulfonamides were reported. Two kinds of complexes were obtained with the stoichiometries [Cu(L)2].H2O and [Cu(L)2(H2O)4].nH2O. They were characterized y IR and electronic spectroscopies and the crystal structure of {Cu(sulfisoxazole)2(H2O)4].2H2O was determined by single crystal X-ray diffraction. It crystallized in the monoclinic C2/c space group with Z = 8. The antimicrobial activity was evaluated for all of the complexes and ligands using the agar dilution test. The results showed that the complexes with five-membered heterocyclic rings were more active that the free sulfonamides while the pyrimidine, pyridine and pyridazine complexes had similar or less activity than the free ligands. In order to find an explanation for this behavior lipophilicity and superoxide dismutase-like activity were tested, showing that the [Cu(sulfamethoxazol)2(H2O)4].3H2O presented the highest antimicrobial and a SOD-like activity comparable with paharmacological active compounds.