Synthesis and Characterization of Heteroleptic Copper and Zinc Complexes with Saccharinate and Aminoacids. Evaluation of SOD-like Activity of the Copper Complexes

SANTI, E; VIERA, I; MOMBRÚ, A.; CASTIGLIONI, J.; BARAN, ENRIQUE J.; TORRE, M.H.

BIOLOGICAL TRACE ELEMENT RESEARCH

HUMANA PRESS INC

Lugar: Totowa, NJ; Año: 2011 vol. 143 p. 1843 - 1855

0163-4984

Five new Cu(II) and Zn(II) heteroleptic complexes with saccharin and amino acids with general stoichiometry Na2[M(sac)2(aa)2].nH2O (M = Cu or Zn, sac = saccharinate anion, aa = aminoacid) were synthesized and characterized by elemental and thermogravimetric analysis, conductimetric measurements and IR, Raman and UV-VIS spectroscopies. In all the complexes  the metal ions coordinated with the amino acids through their terminal amine and carboxylate residues and with saccharin through the heterocyclic N-atom. Besides, the superoxide dismutase-like activity of the heteroleptic copper complexes was evaluated and compared with the homoleptic copper amino acid complexes with the aim to observe the influence of the saccharin coordination.