Analysis of the effect of two novel propargylamines on human triple negative breast cancer cells

PRADA GORI, DENIS N.; BAGLIONI, MARIA VIRGINIA; ROZADOS, VIVIANA R; MARTINEZ AMEZAGA, MAITENA; ERNESTO G. MATA; SCHAROVSKY, O. GRACIELA; GIORDANO, ROCÍO A.; DELPICCOLO, CARINA M; MAINETTI, LEANDRO E.; RICO, MARIA JOSE

Mar del Plata

Congreso; LXIV Reunión Anual de la Sociedad Argentina de Investigación Clínica; 2019

Sociedad Argentina de Investigación Clínica

The lack of effective therapies for some types of cancer, the development of drug resistance and the severe side-effects of the chemotherapeutic agents reduce the clinical efficacy of a large variety of anticancer agents. Thus, there is always a constant need to develop alternative or synergistic anticancer drugs. Previously, we demonstrated the antitumoral activity and apoptotic effect of two propargylamines, MMA06 (06) and MMA4210f3 (4210) in MDA-MB-231 cells. Our aim was to analyse their mechanism of action and evaluate their combined action with Mafosfamide (MAF). The effect of 06 and 4210 (5-100 μM) on colony formation was analyzed using MDA-MB-231 human breast cancer cells. Both compounds decreased the number of colonies being the effect of 06 better than 4210 at concentrations higher than 30 μM (p