Water, our reaction medium

MARCELA RIZZOTTO; ANA PONTORIERO; MARIANO SIMIANI; SEBASTIÁN CINALLI; LAURA MONTI; ESTELA HURE; NATALIA MOSCONI; CLAUDIA TROSSERO; CAROLINA GORR; REGINA FORMIGLI; MARÍA CATALINA OLGUÍN

Rosario

Congreso; 1er. Taller Argentino en Ciencia Medio Ambiental; 2009

<!-- /* Font Definitions */ @font-face {font-family:TimesNewRomanPS; panose-1:0 0 0 0 0 0 0 0 0 0; mso-font-charset:0; mso-generic-font-family:roman; mso-font-format:other; mso-font-pitch:auto; mso-font-signature:3 0 0 0 1 0;} /* Style Definitions */ p.MsoNormal, li.MsoNormal, div.MsoNormal {mso-style-parent:""; margin:0cm; margin-bottom:.0001pt; mso-pagination:widow-orphan; text-autospace:none; font-size:12.0pt; font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman"; mso-ansi-language:PT-BR;} a:link, span.MsoHyperlink {color:blue; text-decoration:underline; text-underline:single;} a:visited, span.MsoHyperlinkFollowed {color:purple; text-decoration:underline; text-underline:single;} @page Section1 {size:612.0pt 792.0pt; margin:2.0cm 2.0cm 2.0cm 70.9pt; mso-header-margin:35.45pt; mso-footer-margin:35.45pt; mso-paper-source:0;} div.Section1 {page:Section1;} -->             Water, our reaction medium   Marcela Rizzotto*, Ana Pontoriero, Mariano Simiani, Sebastián Cinalli, Laura Monti, Estela Hure, Natalia Mosconi, Claudia Trossero, Carolina Gorr, Regina Formigli,            María Catalina Olguín   Faculty of Biochemical and Pharmaceutical Sciences, Rosario University, Suipacha 531, 2000 Rosario, Argentina * e-mail: rizzotto@iquir-conicet.gov.ar     In a part of our project we study systems formed by metal ions and sulfa drugs, working in aqueous medium. We synthesized and characterized metal complex of Hg(II) with sulfanilamide and sodium sulfathiazole (NaST); Co(II) and Co(III) with NaST and recently we begin to study silver complexes of sulfamerazine and sulfadimetoxine. All of these complexes showed antifungal and/or antibacterial activity, many times better than the ligand. Two species were detected in the system Co(II)-sulfathiazole in aqueous solution. The very slight solubility of Hg(II)-ST in water let us think NaST for the removal of Hg(II) from contamined waters. We planned an experience in which an aqueous solution of NaST (0.22 mmol/5 mL) was added to 0.1 mmol HgCl2/5 mL H2O. A white precipitate was immediately obtained. Hg content was determined in aliquots from the floating, which was < 5 ppm 4 hours later. The precipitate did not suffer later dissolution, so, these results let us suggest NaST to remove inorganic Hg(II) from an accidentally spreading in environmental water. In another part of our project we study mutagenic/antimutagenic properties of substances. In this context we analyzed water from Sastre, a little and rural town near Rosario, because during last years it was noticed an enhancement of cancers in young people in the zone. The chemical analysis gave nitrate and arsenic level up to the allowed limit. Samples of water without concentration did not show mutagenic effect with the Ames test, which was performed with Salmonella typhimurium TA98 and TA100 strains. These results did not surprise us, because in general the biological effects of both nitrate and arsenic are not detected with the Ames test. Work is in progress in order to detect possible genotoxic effects by means of the Allium test.