DESIGN OF A SELECTIVE AND TUNABLE RCEYM-HYDROGENATION ONE-POT PROCESS

PERMINGEAT SQUIZATTO, CATERINA; PRADA GORI, DENIS N.; DELPICCOLO, CARINA M.L.

Viena

Simposio; ESOC2019 - 21st European Symposium on Organic Chemistry; 2019

European Symposium on Organic Chemistry

The carbo- and heterocycles systems play a fundamentalrole in the development of new compounds with biological activity. The reaction of metathesis, cyclization and hydrogenationof enynes is an attractive alternative towards the obtention of partially ortotally saturated cyclic and heterocyclic compounds. In this context, enynes weretreated with Ru catalysts in the presence of a hydrogen donor (Scheme 1) allowing us to generate selectivity to the exclusiveformation of a family of interesting derivatives. Different solvents, catalysts,temperatures and hydrogen donors were evaluated to determine the influence of these parameterson the reaction outcome.