INFLUENCE OF PREGELANITIZED STARCH ON THE DISSOLUTION OF PREDNISONE-PEG 6000 SOLID DISPERSIONS FROM HARD GELATIN CAPSULES.

SALOMON, C.J.; LEONARDI D.; LAMAS, M.C.; BARRERA, M.G.

Barcelona, España

Congreso; 6th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology; 2008

APV, International Association for Pharmaceutical Technology, Germany.

Prednisone is the oral steroid chosen for anti-inflammatory or immunosuppressant effects. It is indicated in conditions where corticosteroid therapy is likely to be beneficial, including allergic disorders, immunosuppression, asthma, leukaemia, liver disorders, and cancer chemotherapy. Like many other glucocorticoids belonging to Class II, prednisone is slightly soluble in water and, as a consequence, it can exhibit low and/or variable bioavailability after oral administration. Solid dispersion technique is a very useful tool in dosage form developmentfor increasing the solubility and dissolution rateof poorly soluble drugs. However, there is still limited knowledge about the development of solid dosage forms containing solid dispersions.Due to the increased use of prednisone in immunosuppressive therapy, it was decided to study the potential of solid dispersions for development of fast-release capsules of prednisone using PEG 6000 as hydrophilic carrier. The influence of pregelatinezed starch (PS) on capsules swelling behaviour, disintegration time and drug dissolution rate wasevaluated. The morphology of the polymeric systems was studied using scanning electron microscopy (SEM). Furthermore, infrared spectroscopy (IR) and X-ray powder diffraction(RXPD) were used to investigate possible interactions between the components. , including allergic disorders, immunosuppression, asthma, leukaemia, liver disorders, and cancer chemotherapy. Like many other glucocorticoids belonging to Class II, prednisone is slightly soluble in water and, as a consequence, it can exhibit low and/or variable bioavailability after oral administration. Solid dispersion technique is a very useful tool in dosage form developmentfor increasing the solubility and dissolution rateof poorly soluble drugs. However, there is still limited knowledge about the development of solid dosage forms containing solid dispersions.Due to the increased use of prednisone in immunosuppressive therapy, it was decided to study the potential of solid dispersions for development of fast-release capsules of prednisone using PEG 6000 as hydrophilic carrier. The influence of pregelatinezed starch (PS) on capsules swelling behaviour, disintegration time and drug dissolution rate wasevaluated. The morphology of the polymeric systems was studied using scanning electron microscopy (SEM). Furthermore, infrared spectroscopy (IR) and X-ray powder diffraction(RXPD) were used to investigate possible interactions between the components.