IQUIR   05412
INSTITUTO DE QUIMICA ROSARIO
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
INDOLE-PYRIDO[2,3-d]PYRIMIDINE HYBRIDS: THREE-COMPONENT SYNTHESIS AND BINDING STUDIES AGAINST DOPAMINERGIC RECEPTORS
Autor/es:
MANUEL NOGUERAS; JUSTO COBO; DIDIER VARGAS; JORGE TRILLERAS VÁSQUEZ; MARÍA DE LOS ANGELES ÁLVAREZ; SEBASTIÁN A. ANDÚJAR; RICARDO D. ENRIZ; DIEGO CORTÉS
Lugar:
Lisboa
Reunión:
Simposio; 19th European Symposium on OrganicChemistry; 2015
Institución organizadora:
Sociedade Portuguesa de Química
Resumen:
We are here reporting the MCR?s between corresponding 4-aminopyrimidine 1a or 1b, 3-(1H-indol-3-yl)-3-oxopropanenitrile 2 and aromatic aldehydes 3, both at classical reflux in acetic acid and under free-solvent MWI-assisted with InCl3 as a catalyst, to afford the hybrids 4 and 5, with better results for these last environmentally friendlier conditions. cagents on three of those compounds, displaying a remarkable selectivity for D2 receptor and low affinity for D1 receptor.