IQUIR   05412
INSTITUTO DE QUIMICA ROSARIO
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Formulation of praziquantel binary and ternary solid dispersions into hard-gelatin capsules. Effects of the carriers on the drug dissolution profile.
Autor/es:
SILVINA ORLANDI; DARÍO LEONARDI; CLAUDIO SALOMON
Lugar:
Cordoba
Reunión:
Congreso; III Reunión Internacional de Ciencias Farmacéuticas RICIFA 2014; 2014
Resumen:
Solid dispersions (SDs) are one of the most promising tools to improve the solubility, dissolution rate and oral bioavailability of drugs with low aqueous solubility. Even though this technique has been widely applied in the last decades, there is still limited knowledge about the successful formulation of binary and ternary SDs into final solid dosage forms. The aim of the present study was to evaluate the dissolution of praziquantel (PZQ), as model drug, through the formation of binary and ternary SDs, and to compare the dissolution profiles of the SDs with those of formulated SDs in hard-gelatin capsules. SDs systems were prepared by the solvent evaporation method using as polymeric carrier polyvinylpyrrolidone (PVP) and polyethylene glycol (PEG) and poloxamer 237 as surfactant agent. Dissolution studies, differential scanning calorimeter (DSC), X-ray diffractometry (XRD) and infrared spectroscopy were used to characterize the SDs of PZQ. The results showed that PZQ release rates from the binary SDs were evidently higher than the dissolution rate of drug alone. Corresponding physical mixtures also demonstrated higher dissolution profiles than PZQ alone. However, it was observed a similar dissolution profiles between the SDs and the PMs. The dissolution rate of PZQ from the ternary SDs was very similar to the binary systems showing that the influence of the surfactant on the drug dissolution was negligible. On the other hand, minor differences were found in the PZQ dissolution rate from capsules in the binary and ternary systems indicating that further processing of the solid dispersions did not greatly modify the drug dissolution rate. By DSC, it was observed a remarkable difference between the thermograms of PZQ alone and the SDs. In conclusion, PZQ binary and ternary SDs formulated into hard-gelatin capsules were confirmed as a valid approach to the improvement of drug dissolution.