Evaluation of polymers for the encapsulation of superoxide dismutase into microparticles

CLAUDIO SALOMON; CAVIGLIA MAGDALENA; RAMANZIN FABRICIO

Pamplona

Simposio; 19th International Symposium on MICROENCAPSULATION; 2013

International Microencapsulation Society

Superoxide Dismutasa (SOD) is an essential enzyme, which protects cells from oxidative damage by catalyzing the reduction of the O-2 to H2O2 and molecular oxygen (O2). Its use promoted encouraging results in prevention protocols against aging, and some very important diseases, such as cancer, arteriosclerosis and age-dependent immune deficiency. However, SOD has a short half-live in vivo requiring multiple treatments to provide efficacy. They are also unstable in biological fluids, and not fully absorbed from the gastrointestinal tract because of their relatively high molecular weights. Thus, the development of more suitable formulations for the delivery of SOD is required. In this context, microencapsulation may represent a convenient strategy to protect and to release in a controlled manner an active compound, such as SOD and other proteins. Microparticles present matrix structure in which the molecules can be absorbed either at the surface or throughout the interior of the particle. On the other hand, have a shell-type structure in which the active compound is encapsulated in the middle of the particle and surrounded by a protein or polymeric coat. Therefore, the aim of this work was to evaluate different polymers as potencial carriers for the production of spray-dried microparticles containing SOD