IQUIR   05412
INSTITUTO DE QUIMICA ROSARIO
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Benznidazole-loaded chitosan microparticles for the treatment of Chagas? disease
Autor/es:
BARRERA M.G.; LEONARDI D.; SALOMON C.J; LAMAS M.C.
Lugar:
Anatolia
Reunión:
Simposio; 18º International Symposium of Microencapsulation; 2011
Resumen:
The aim of this work was to evaluate the bioavailability of Benznidazole from chitosan microparticles for the treatment of Chagas? disease, in comparison with an aqueous suspension of the same drug. Benznidazole-chitosan microparticles were prepared by the coacervation method in aqueous solution. Chagas? disease is the most prevalent in the poverty neglected parasitic diseases in America, affecting around 20 million people. Benznidazole (BZL) is one of the chosen drugs for the treatment of this infection, caused by the Trypanosoma cruzi. Included in the WHO list of essential medicines, this antiparasite active compound is available in a unique 100 mg tablet presentation and the common dosage is 5-7 mg/kg/day for 30-60 days (Urbina, 2010). The aim of this work was to design BZL-loaded chitosan microparticles and to evaluate the plasma pharmacokinetics as compared with an aqueous BZL suspension. Chitosan (CH) was chosen as a carrier due to its biodegradability (Bagheri-Khoulenjani et al. 2009), non-toxicity and good biocompatibility.