Advances in Metal-Mediated Solid-Phase Synthesis of Heterocyclic Compounds

MATA, E. G.; LA-VENIA, A.; DELPICCOLO, C. M. L.

Solid-Phase Synthesis of Nitrogenous Heterocycles

Springer International Publishing AG

Año: 2017; p. 95 - 137

While heterocycles are a key feature frequently found in compounds with pharmaceutical or agrochemical interest, the combination between solidsupported synthesis and organometallic chemistry has demonstrated to be a helpful tool for the preparation of that class of biologically relevant structures. From the more disclosed Hüisgen 1,3-dipolar cycloaddition, the palladium-catalyzed synthesis of indoles and the ruthenium carbene-mediated preparation of heterocycles by ring-closing metathesis (RCM), to the less developed use of gold and iron in polymer-supported chemistry, this survey offers an overview of the solid-phase application of metal-mediated chemistry to the generation of libraries of a variety of heterocyclic systems.