Recent advances in the solid-phase synthesis of N-heteroaromatic five membered rings

SEBASTIÁN A. TESTERO; ANDRES A. POEYLAUT-PALENA; ERNESTO G. MATA

Modern Approaches to the Synthesis of O- and N-Heterocycles

Research Signpost

Lugar: Trivandrum; Año: 2007; p. 341 - 372

Combinatorial chemistry and related high-speed synthesis are powerful tools for the discovery of new drugs. In particular, solid-phase organic synthesis (SPOS) is widely used for the preparation of a large number of structurally diverse small organic molecules in order to accelerate lead generation and lead optimization. Due to their potential biological activities, the synthesis of five-membered ring heteroaromatics is of great importance in medicinal chemistry. Consequently, different solid-phase approaches for the preparation of these heterocycles have been recently introduced. This chapter covers the synthesis of N-heteroaromatic five membered rings that has been reported in the literature in the last seven years.