ANTIFUNGAL ACTIVITY AND TOXICITY STUDIES OF FLAVANONES ISOLATED FROM TESSARIA DODONEIFOLIA AERIAL PARTS

CARABAJAL TORREZ, J.A.; SAMPIETRO, D.A.; SOBERÓN, J. R.; AGUILAR, F.A.; DE LUCO, J.F. ; SGARIGLIA, M. A.; PERO, E.J.; LABADIE, G.

Heliyon

Cell Press

Lugar: Cambridge; Año: 2020

2405-8440

Tessaria dodoneifolia [Asteraceae] is traditionally employed in Northwestern Argentina for fungal infections treatment. We report the antifungal activity guided isolation and identification of substances from aerial parts of this species, both individually and in combination with fluconazole (FLU), against Candida albicans strains. Two antifungal flavanones were identified as naringenin (NAR) and pinocembrin (PIN). These compounds could individually inhibit the growth of C. albicans strains. Combinations of NAR and PIN with FLU were synergistic against the FLU resistant and sensitive C. albicans strains. Genotoxic and cytotoxic evaluations were also performed. NAR, PIN and their combinations with FLU did not have a genotoxic effect on Bacillus subtilis rec strains. Finally, the identified compounds did not show cytotoxicity at concentrations below 80 µg/mL.