IQUIR   05412
INSTITUTO DE QUIMICA ROSARIO
Unidad Ejecutora - UE
artículos
Título:
Expanding the scope of synthetic 1,2,4-trioxanes towards Trypanosoma cruzi and Leishmania donovani
Autor/es:
MARTÍNEZ SAYÉ M; LA VENIA A; MEDRAN N; TEKWANI BL; PEREIRA CA; LABADIÉ G
Revista:
BIORGANIC AND MEDICINAL CHEMISTRY LETTERS
Editorial:
Elsevier
Referencias:
Lugar: Amsterdam; Año: 2020 vol. 30
ISSN:
0960-894X
Resumen:
A series of synthetic 1,2,4-trioxanes related to artemisinin was tested against L. donovani and T. cruzi parasites. This screening identified some active compounds, with key common structural features. Interestingly, these selected trioxanes were efficient against both parasites, and achieved antiparasitic activities comparable or superior than those presented by the corresponding reference drugs, artemisinin and artesunate. This study represents the first example of synthetic trioxanes evaluated on T. cruzi and provides possible candidates for developing new drugs for the treatment of leishmaniasis and Chagas disease.