IQUIR   05412
INSTITUTO DE QUIMICA ROSARIO
Unidad Ejecutora - UE
artículos
Título:
2,2,2-trifluoroethanol-promoted access to symmetrically 3,3-disubstituted quinoline-2,4-diones
Autor/es:
SELVERO, MARCEL MANKE; SCHULZ-LANG, ERNESTO; ABRAM, ULRICH; LARGHI, ENRIQUE L.; LEDESMA, GABRIELA N.; MOREL, ADEMIR FARIAS
Revista:
JOURNAL OF FLUORINE CHEMISTRY
Editorial:
ELSEVIER SCIENCE SA
Referencias:
Año: 2020 vol. 234 p. 109520 - 109526
ISSN:
0022-1139
Resumen:
The unprecedented use of 2,2,2-trifluoroethanol as reaction solvent provided a facile and convenient access to symmetrically 3,3-disubstitued quinoline-2,4-diones in moderate to excellent yields and high regioselectivity, by reaction of 4-hydroxy-2-quinolones with electrophiles like methyl iodide, as well as benzyl and allyl bromides in the presence of K2CO3. Silver (I) oxide is required to increase the yield of the methylations.