ANTIFUNGAL CAPACITY OF SULFADIMETOXINE-Ag(I) COMPLEXES

MONTI, L.; MOSCONI, N.; HURE, E.; PONTORIERO, A.; ZACCHINO, S.; RAIMONDI,M.; RIZZOTTO, M.

BIOCELL

INST HISTOL EMBRIOL-CONICET

Lugar: Mendoza; Año: 2009 vol. 33 p. 22 - 22

0327-9545

<!-- /* Style Definitions */ p.MsoNormal, li.MsoNormal, div.MsoNormal {mso-style-parent:""; margin:0cm; margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:12.0pt; font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";} a:link, span.MsoHyperlink {color:blue; text-decoration:underline; text-underline:single;} a:visited, span.MsoHyperlinkFollowed {color:purple; text-decoration:underline; text-underline:single;} @page Section1 {size:612.0pt 792.0pt; margin:70.85pt 3.0cm 70.85pt 3.0cm; mso-header-margin:36.0pt; mso-footer-margin:36.0pt; mso-paper-source:0;} div.Section1 {page:Section1;} --> ANTIFUNGAL CAPACITY OF SULFADIMETOXINE-Ag(I) COMPLEXES 1Monti, Laura; 1Mosconi, Natalia; 1Hure, Estela; 1Pontoriero, Ana; 2Zacchino, Susana; 2 ,3Raimondi, Marcela, 1Rizzotto, Marcela* 1IQUIR División Inorgánica;  2Cátedra de Farmacognosia, Facultad de Ciencias Bioquímicas y Farmacéuticas, 3Cátedra de Microbiología, Facultad de Ciencias Médicas UNR, Suipacha 531, 2000 Rosario. E-mail: mrizzott@fbioyf.unr.edu.ar                       During last decades there was a large increment of human fungal infections, which could be fatal in inmunodeficient patients. Several antifungal show toxicity and resistance, reducing the therapeutic options. In general, metal complexes of sulfa drugs enhance biological properties of the free ligand, like silver sulfadiazine. In this work we assayed silver-sulfadimetoxine complexes as antifungal ones. A white solid was obtained by mixture of aqueous solutions of AgNO3 and sulfadimetoxine (SDM). The white solid was washed, in different synthetic procedures, with water or with ethanol, and crystallized from DMSO. The little differences observed among the complexes could be due to a H2O. The minimum inhibitory concentration (MIC) and the minimum fungicide concentration (MFC) of both Ag-SDM complexes, SDM and AgNO3 were determined, according to NCCLS specifications, for the following fungi: C. albicans, C. tropicalis, S. cerevisiae, C. neoformans, A. fumigatus, A. flavus, A. niger, M. gypseum, T. rubrum, T. mentagrophytes. All the fungi were susceptible to both Ag-SDM complexes. The mayor inhibition was observed with C. neoformans and S. cerevisiae (MIC = 15.6 and 125 mg/mL; and MFC = 62.5 and 125 mg/mL respectively). It should be noted that none of the assayed fungi was inhibit by the free ligand, so, the silver complexation seem to play an important role on the antifungal activity