IQUIR 05412
INSTITUTO DE QUIMICA ROSARIO
Unidad Ejecutora - UE
artículos
Título:
Synthesis of triazole derivatives of levoglucosenone as promising anticancer agents. Effective exploration of the chemical space through retro-aza-Michael//aza-Michael isomerizations
Autor/es:
TSAI, YI-HSUAN; GIRARDINI, JAVIER E.; SUÁREZ, ALEJANDRA G.; BORINI ETICHETTI, CARLA M.; MARTINS, FELIPE TERRA; SAROTTI, ARIEL M.; BORINI ETICHETTI, CARLA M.; MARTINS, FELIPE TERRA; SAROTTI, ARIEL M.; DI BENEDETTO, CAROLINA; SPANEVELLO, ROLANDO A.; DI BENEDETTO, CAROLINA; SPANEVELLO, ROLANDO A.; TSAI, YI-HSUAN; GIRARDINI, JAVIER E.; SUÁREZ, ALEJANDRA G.
Revista:
JOURNAL OF ORGANIC CHEMISTRY
Editorial:
AMER CHEMICAL SOC
Referencias:
Lugar: Washington; Año: 2018 vol. 83 p. 3516 - 3528
ISSN:
0022-3263
Resumen:
The design and synthesis of biomass-derived triazoles and the in vitro evaluation as potential anticancer agents is described. The discovery of base-catalyzed retro-aza-Michael//aza-Michael isomerizations allowed the exploration of the chemical space by affording novel types of triazoles, difficult to obtain otherwise. Following this strategy, 2,4-disubstituted-1,2,3-triazoles could be efficiently obtained from the corresponding 1,4-disubstituted analogues.
