Design of a Selective Ring-Closing Enyne Metathesis-Reduction for the Generation of Different Synthetic Scaffolds

CORNIER, PATRICIA G.; PERMINGEAT SQUIZATTO, CATERINA; PRADA GORI, DENIS N.; DELPICCOLO, CARINA M. L.; CORNIER, PATRICIA G.; PERMINGEAT SQUIZATTO, CATERINA; PRADA GORI, DENIS N.; DELPICCOLO, CARINA M. L.

JOURNAL OF ORGANIC CHEMISTRY

AMER CHEMICAL SOC

Año: 2018 vol. 83 p. 12798 - 12805

0022-3263

A tandem process of ring-closing enyne metathesis (RCEYM)-reduction using modern ruthenium catalysts and a hydrogen donor is described. This straightforward methodology is useful for C(sp3) generation under mild reaction conditions. Variables such as solvent, catalyst, hydride source, and temperature were adjusted toward the exclusive formation of different products.