IQUIR   05412
INSTITUTO DE QUIMICA ROSARIO
Unidad Ejecutora - UE
artículos
Título:
Molecular diversity by olefin cross-metathesis on solid support. Generation of libraries of biologically promising β-lactam derivatives
Autor/es:
MÉNDEZ, LUCIANA; MATA, ERNESTO G.; POEYLAUT-PALENA, ANDRÉS A.
Revista:
MOLECULES
Editorial:
MOLECULAR DIVERSITY PRESERVATION INTERNATIONAL-MDPI
Referencias:
Año: 2018 vol. 23
ISSN:
1420-3049
Resumen:
The application of the reagent-based diversification strategy for generation of libraries of biologically promising β-lactam derivatives is described. Key features are the versatility of the linker used and the cross-metathesis functionalization at the cleavage step. From an immobilized primary library, diversity was expanded by applying different cleavage conditions, leading to a series of cholesterol absorption inhibitor analogues together with interesting hybrid compounds through incorporation of a chalcone moiety.