IQUIR   05412
INSTITUTO DE QUIMICA ROSARIO
Unidad Ejecutora - UE
artículos
Título:
Preparation and Physical Characterization of a Diclofenac-Ranitidine
Autor/es:
KAUFMAN, T. S.; GAITANO, ROBERTINO; CALVO, NATALIA L; BRUSAU, ELENA; MAGGIO, R. M.; NARDA, GRISELDA
Revista:
JOURNAL OF PHARMACEUTICAL SCIENCES
Editorial:
JOHN WILEY & SONS INC
Referencias:
Lugar: New York; Año: 2016 vol. 105 p. 1258 - 1268
ISSN:
0022-3549
Resumen:
Mixing aqueous solutions of sodium diclofenac (DIC-Na) and ranitidine hydrochloride (RAN$HCl) affordedan off-white solid (DIC-RAN) that was investigated from the microscopic, thermal, diffractometric,spectroscopic, and functional (chemometrics-assisted dissolution) points of view. The solid has a 2:1(DIC:RAN) molar ratio according to 1H nuclear magnetic resonance spectroscopy. It is thermally stable,displaying a broad endothermic signal centered at 105C in the thermogram, and its characteristic reflectionsin the powder X-ray diffractogram remained unchanged after a 3-month aging period. Scanningelectron microscopy micrographs uncovered its morphology, whereas the spectral data suggested aninteraction between the carboxylic acid of DIC and the alkyldimethylamino moiety of RAN. The dissolutionof DIC-RAN was monitored at different pH values by an ultraviolet/chemometrics procedure, beingcomplete within 5 min at pH 6.8. This compares favorably with the dissolution of a DIC-Na sample of thesame particle size.