IQUIR 05412
INSTITUTO DE QUIMICA ROSARIO
Unidad Ejecutora - UE
artículos
Título:
Synthesis of a Small Library of Imidazolidin-2-ones using Gold Catalysis on Solid Phase.
Autor/es:
MEDRAN NOELIA S.; LA VENIA AGUSTINA ; TESTERO SEBASTIÁN A.; VIKTOR KRCHNAK
Revista:
ACS Combinatorial Science
Editorial:
American Chemical Society
Referencias:
Año: 2016 vol. 18 p. 482 - 489
ISSN:
2156-8952
Resumen:
An efficient and high-yielding solid phase synthesis of a small library of imidazolidin-2-ones and imidazol-2-ones was carried out employing a high chemo- and regio-selective gold-catalyzed cycloisomerization as a key step. Polymer-supported amino acids derivatized with several alkynes functionalities combined with tosyl- and phenyl-ureas have been subjected to gold-catalysis exhibiting exclusively C?N bond formation. The present work proves the potential of solid phase synthesis and homogeneous gold catalysis as an efficient and powerful synthetic tool for the generation of drug-like heterocycles.
