Photoinduced Oxygen Capture on Immobilized Dienone Systems.First Solid-Phase Synthesis of Trioxane Scaffolds

AGUSTINA LA-VENIA,; ERNESTO G. MATA; MIRTA P. MISCHNE

J. Comb. Chem.

Año: 2008 vol. 10 p. 504 - 506

1520-4766

Solid-phase synthesis has developed to become a key tool in many aspects of chemistry in general and in drug discovery process in particular. The solid-supported synthesis of cyclic, nonoligomeric structures has been the focus of recent investigations with application toward a variety of natural product scaffolds and drug-like molecules. 1 Particularly, heterocyclic compounds continue to be attractive targets because they often exhibit diverse and important biological properties.2 Thus, the library concept has been extended to hetero- and polycyclic structures, and it has stimulated the adaptation to solid support of many procedures for carbon-carbon and carbonheteroatom bond formation. bond formation. bond formation. bond formation. has been extended to hetero- and polycyclic structures, and it has stimulated the adaptation to solid support of many procedures for carbon-carbon and carbonheteroatom bond formation. bond formation. bond formation. bond formation. has been extended to hetero- and polycyclic structures, and it has stimulated the adaptation to solid support of many procedures for carbon-carbon and carbonheteroatom bond formation. bond formation. bond formation. bond formation. has been extended to hetero- and polycyclic structures, and it has stimulated the adaptation to solid support of many procedures for carbon-carbon and carbonheteroatom bond formation. bond formation. bond formation. bond formation. be attractive targets because they often exhibit diverse and important biological properties.2 Thus, the library concept has been extended to hetero- and polycyclic structures, and it has stimulated the adaptation to solid support of many procedures for carbon-carbon and carbonheteroatom bond formation. bond formation. bond formation. bond formation. has been extended to hetero- and polycyclic structures, and it has stimulated the adaptation to solid support of many procedures for carbon-carbon and carbonheteroatom bond formation. bond formation. bond formation. bond formation. has been extended to hetero- and polycyclic structures, and it has stimulated the adaptation to solid support of many procedures for carbon-carbon and carbonheteroatom bond formation. bond formation. bond formation. bond formation. has been extended to hetero- and polycyclic structures, and it has stimulated the adaptation to solid support of many procedures for carbon-carbon and carbonheteroatom bond formation. bond formation. bond formation. bond formation. be attractive targets because they often exhibit diverse and important biological properties.2 Thus, the library concept has been extended to hetero- and polycyclic structures, and it has stimulated the adaptation to solid support of many procedures for carbon-carbon and carbonheteroatom bond formation. bond formation. bond formation. bond formation. has been extended to hetero- and polycyclic structures, and it has stimulated the adaptation to solid support of many procedures for carbon-carbon and carbonheteroatom bond formation. bond formation. bond formation. bond formation. has been extended to hetero- and polycyclic structures, and it has stimulated the adaptation to solid support of many procedures for carbon-carbon and carbonheteroatom bond formation. bond formation. bond formation. bond formation. has been extended to hetero- and polycyclic structures, and it has stimulated the adaptation to solid support of many procedures for carbon-carbon and carbonheteroatom bond formation. bond formation. bond formation. bond formation. be attractive targets because they often exhibit diverse and important biological properties.2 Thus, the library concept has been extended to hetero- and polycyclic structures, and it has stimulated the adaptation to solid support of many procedures for carbon-carbon and carbonheteroatom bond formation. bond formation. bond formation. bond formation. has been extended to hetero- and polycyclic structures, and it has stimulated the adaptation to solid support of many procedures for carbon-carbon and carbonheteroatom bond formation. bond formation. bond formation. bond formation. has been extended to hetero- and polycyclic structures, and it has stimulated the adaptation to solid support of many procedures for carbon-carbon and carbonheteroatom bond formation. bond formation. bond formation. bond formation. has been extended to hetero- and polycyclic structures, and it has stimulated the adaptation to solid support of many procedures for carbon-carbon and carbonheteroatom bond formation. bond formation. bond formation. bond formation. Particularly, heterocyclic compounds continue to be attractive targets because they often exhibit diverse and important biological properties.2 Thus, the library concept has been extended to hetero- and polycyclic structures, and it has stimulated the adaptation to solid support of many procedures for carbon-carbon and carbonheteroatom bond formation. bond formation. bond formation. bond formation. has been extended to hetero- and polycyclic structures, and it has stimulated the adaptation to solid support of many procedures for carbon-carbon and carbonheteroatom bond formation. bond formation. bond formation. bond formation. has been extended to hetero- and polycyclic structures, and it has stimulated the adaptation to solid support of many procedures for carbon-carbon and carbonheteroatom bond formation. bond formation. bond formation. bond formation. has been extended to hetero- and polycyclic structures, and it has stimulated the adaptation to solid support of many procedures for carbon-carbon and carbonheteroatom bond formation. bond formation. bond formation. bond formation. 2 Thus, the library concept has been extended to hetero- and polycyclic structures, and it has stimulated the adaptation to solid support of many procedures for carbon-carbon and carbonheteroatom bond formation. bond formation. bond formation. bond formation. -carbon and carbonheteroatom bond formation.