IQUIR 05412
INSTITUTO DE QUIMICA ROSARIO
Unidad Ejecutora - UE
artículos
Título:
Pericyclic Cascade toward Isochromenes: Application to the Synthesis of Alkaloid Benzosimuline
Autor/es:
MISCHNE, M. P.; RIVEIRA, M. J.; LA-VENIA, A.
Revista:
JOURNAL OF ORGANIC CHEMISTRY
Editorial:
AMER CHEMICAL SOC
Referencias:
Lugar: Washington; Año: 2016 vol. 81 p. 7977 - 7983
ISSN:
0022-3263
Resumen:
The synthesis of biologically active alkaloid benzosimuline, isolated from the shrub Zanthoxylum simulans, is reported. Key transformation involves an oxa-6π electrocyclic ringopening/hetero-Diels−Alder pericyclic cascade. Although the last aromatization step proved to be cumbersome, this work unfolds a unique route to access interesting molecules from simpleprecursors
