IQUIR   05412
INSTITUTO DE QUIMICA ROSARIO
Unidad Ejecutora - UE
artículos
Título:
Synthesis, Structure and SOD Activity of Mn Complexes With Symmetric Schiff Base Ligands Derived From Pyridoxal
Autor/es:
SIGNORELLA, S.; DAIER, V.; LEDESMA, G. N.; PALOPOLI, C.; BACK, D. F.; SCHULZ-LANG, E.; ROSSINI KOPPE, C.; EBANI, P.; BRUM PEREIRA, M.; GIACOMELI, C.; PIQUINI, P. C.
Revista:
POLYHEDRON
Editorial:
PERGAMON-ELSEVIER SCIENCE LTD
Referencias:
Lugar: Amsterdam; Año: 2015 vol. 102 p. 176 - 184
ISSN:
0277-5387
Resumen:
This study describes the synthesis, crystal structure and antioxidant activity of manganese(III) complexes with Schiff-base ligands obtained from condensation of pyridoxal with alkyl diamines: [Mn(pyr2en)(H2O)2]Cl?4H2O, [Mn(pyr2en)(H2O)(CH3OH)]Cl, [Mn(pyr2pn)(H2O)2]ClO4 and [Mn2(pyr2bn)3]?6H2O, where H2pyr2en = 1,2-bis(pyridoxylidenamino)ethane, H2pyr2pn = 1,3-bis(pyridoxylidenamino)propane and H2pyr2bn = 1,4-bis(pyridoxylidenamino)butane. The four complexes catalyze the dismutation of superoxide efficiently with IC50 values in the range of 1.22 to 2.15 M, evaluated through the nitro blue tetrazolium photoreduction inhibition superoxide dismutase assay, in aqueous solution of pH 7.8. The length of the alkyl spacer in the diamine fragment plays a key role in the antioxidant activity of these complexes, with [Mn(pyr2pn)(H2O)2]ClO4 showing the lowest IC50 value.