IQUIR   05412
INSTITUTO DE QUIMICA ROSARIO
Unidad Ejecutora - UE
artículos
Título:
In vitro anticancer activity and SAR studies of triazolyl aminoacyl(peptidyl) penicillins
Autor/es:
CORNIER P.G.; DELPICCOLO CM; MASCALI FLORENCIA; BOGGIÁN D.B; MATA E.G.; M CARDENAS; BLANK VC; ROGUIN, L.P.
Revista:
Med Chem Comm
Editorial:
RSC Publishing
Referencias:
Lugar: Cambridge; Año: 2014 vol. 5 p. 214 - 218
ISSN:
2040-2503
Resumen:
A library of triazolyl aminoacyl(peptidyl) penicillins was designed, synthesized, and evaluated for their antiproliferative activity against HeLa and B16-F0 cell lines. 10 Structure-activity-relationship studies were carried out, and minimal structural requirements were determinated. Among the tested compounds, derivatives 7f, 7p and 7m demonstrated the highest anticancer activity and a promising selectivity profile against these two cell lines.