IQUIR   05412
INSTITUTO DE QUIMICA ROSARIO
Unidad Ejecutora - UE
artículos
Título:
Synthesis of Symmetrically Substituted 3,3-Dibenzyl-4-hydroxy-3,4-dihydro-1H-quinolin-2-ones, as Novel Quinoline Derivatives with
Autor/es:
FERRETTI, M.; NETO, A. T.; FARIAS MOREL, A.; KAUFMAN, T. S.; LARGHI, E. L.
Revista:
EUROPEAN JOURNAL OF MEDICAL CHEMISTRY
Editorial:
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
Referencias:
Lugar: Paris; Año: 2014 vol. 81 p. 253 - 256
ISSN:
0223-5234
Resumen:
A novel series of symmetrically substituted 15 3,3-dibenzyl-4-hydroxy-3,4-dihydro-1H-quinolin-2-ones was synthesized and tested as antimicrobials. Theheterocycles exhibited minimum inhibitory concentrations and minimum lethalconcentration values up to the same order of magnitude than levofloxacin, employed ascomparator. Structural factors affecting the activity were explored along threediversification points, including the substituents of both aromatic rings of the 3-benzylmoieties, the functionalization of the homocyclic ring of the heterocycle, and thesubstitution of the quinolonic nitrogen atom. 6-Chloro and 3,3-bis(4‟-chlorobenzyl)derivatives showed the lower MIC values. Optimally substituted heterocycles weresynthesized, which exhibited enhanced activity.