IQUIR   05412
INSTITUTO DE QUIMICA ROSARIO
Unidad Ejecutora - UE
artículos
Título:
Unexpected Performance of Physical Mixtures over Solid Dispersions on the Dissolution Behavior of Benznidazole from Tablets
Autor/es:
LEONARDI D.; SALOMON C.J.
Revista:
JOURNAL OF PHARMACEUTICAL SCIENCES
Editorial:
JOHN WILEY & SONS INC
Referencias:
Lugar: New York; Año: 2013 vol. 102 p. 1016 - 1023
ISSN:
0022-3549
Resumen:
This work investigated the feasibility of developing benznidazole (BZL) tablets,
allowing fast, reproducible, and complete drug dissolution, by compressing BZL-Polyethylene
Glycol (PEG) 6000 physical mixtures (PMs) and solid dispersions (SDs). SDs were prepared
by the solvent evaporation method at different drug:polymer ratios (w/w). BZL-PEG 6000 formulations
were characterized by X-ray diffraction (XRD), scanning electron microscopy, and
dissolution studies. The preparation of SD-based BZL tablets by the wet granulation method
was carried out and the influence of pregelatinized starch (PS) and starch (S) on the disintegration
time and drug dissolution rate was analyzed. SDs showed a significant improvement
in the release profile of BZL as compared with the pure drug. As demonstrated by XRD, the
crystalline character of BZL remained almost unaltered in both PMs and SDs. BZL release from
the PEG 6000 tablets increased by the presence of PS instead S. Unexpectedly, the BZL release
from tablets containing PMs was almost equal as compared with the BZL release from tablets
containing SDs. In conclusion, the results suggest that PEG 6000 and PS are suitable additives
for the development of BZL tablets with enhanced dissolution behavior through the preparation
of ordinary PMs, instead the laborious SDs.