Spray drying formulation of albendazole microspheres by experimental design. In vitro?in vivo studies

GARCIA, A.; LEONARDI, D.; PICCIRILLI, G.N.; MAMPRIN, M.; OLIVIERI, A.C.; LAMAS, M.C.

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

TAYLOR & FRANCIS INC

Lugar: Londres; Año: 2013 p. 1 - 9

0363-9045

Both an experimental design and optimization techniques were carried out for the development of chitosan?pectin?carboxymethylcellulose microspheres to improve the oral absorption of albendazole as a model drug. The effect of three different factors (chitosan, pectin and carboxy methyl cellulose concentrations) was studied on five responses: yield, morphology, dissolution rate at 30 and 60 min, and encapsulation efficiency of the microspheres. During the screening phase, the factors were evaluated in order to identify those which exert a significant effect. Simultaneous multiple response optimizations were then used to find out experimental conditions where the system shows the most adequate results. The optimal conditions were found to be: chitosan concentration, 1.00% w/v, pectin concentration 0.10% w/v and carboxymethylcellulose concentration 0.20% w/v. The bioavailability of the loaded drug in the optimized microspheres was evaluated in Wistar rats which showed an area under curve (AUC) almost 10 times higher than the pure drug.