IQUIR   05412
INSTITUTO DE QUIMICA ROSARIO
Unidad Ejecutora - UE
artículos
Título:
A Multivariate curve resolution approach to the study of the degradation kinetics of valsartan under photolytic and acid conditions
Autor/es:
KAUFMAN, T. S.; BIANCHINI, R. M.
Revista:
INTERNATIONAL JOURNAL OF CHEMICAL KINETICS
Editorial:
JOHN WILEY & SONS INC
Referencias:
Lugar: New York; Año: 2013 vol. 45 p. 734 - 745
ISSN:
0538-8066
Resumen:
The analysis of UV-spectrophotometric data with second-order chemometrics techniques, including multivariate curve resolution with alternating least squares (MCR-ALS) and hybrid hard- and soft MCR (HS-MCR), was examined as an alternative tool for studying the kinetics of drug degradation under stress conditions, employing valsartan (VAL) as a model drug.     Despite small structural and spectroscopic differences between VAL and its degradation products, MCR-ALS and HS-MCR were able to detect the generation of two photo-neutral degradation products (DP-1 and DP-2) and a single acid hydrolysis product (DP-3), providing good approximations to their pure spectra and concentration profiles, from which estimations of the kinetics profiles and rate constants were obtained. Kinetic models based on first-order reactions explained the degradation processes. MCR-ALS and HS-MCR analyses yielded similar rate constants; however, the latter was capable of more properly fitting the experimental data to a kinetic model in the case of drug photolysis. The results were confirmed by comparison with data obtained by HPLC analysis of the degraded samples.