IQUIR   05412
INSTITUTO DE QUIMICA ROSARIO
Unidad Ejecutora - UE
artículos
Título:
Design, characterization and in vitro evaluation of antifungal polymeric films
Autor/es:
REAL, D.; MARTINEZ, M.V.; FRATTINI, A.; SOAZO, M.; LUQUE, A.G.; BIASOLI, M.S.; SALOMON, C.J.; OLIVIERI, A.C.; LEONARDI, D.
Revista:
AAPS PHARMSCITECH
Editorial:
SPRINGER
Referencias:
Año: 2012
ISSN:
1530-9932
Resumen:
The objective of the present paper was the development and the full
characterization of antifungal films. Econazole nitrate (ECN) was loaded in a polymeric matrix
formed by chitosan (CH) and carbopol 971NF (CB). Polyethylene glycol 400 and sorbitol were
used as plasticizing agents. The mechanical properties of films were poorer when the drug was
loaded, probably because crystals of ENC produces network outages and therefore reduces the
polymeric interactions between the polymers. Polymers-ECN and CH-CB interactions were
analyzed by Fourier-transform infrared spectroscopy (FTIR), thermal gravimetry analysis and
differential thermal analysis (DTA-TGA). ECN did not show structure alterations when loaded
into the films. In scanning electron microphotographs and atomic force microscopy analysis,
films prepared with CB showed an evident wrinkle pattern probably due to the strong
interactions between the polymers, which were observed by FTIR and DTA-TGA. The in vitroin vitro
activity of the formulations against Candida krusei and Candida parapsilosis was twice as
greater as the commercial cream, probably as a result of the antifungal combination of the drug
with the CH activity. All these results suggest that these polymeric films containing ECN are
potential candidates in view of alternatives dosages forms for the treatment of the yeast assayed.
greater as the commercial cream, probably as a result of the antifungal combination of the drug
with the CH activity. All these results suggest that these polymeric films containing ECN are
potential candidates in view of alternatives dosages forms for the treatment of the yeast assayed.
greater as the commercial cream, probably as a result of the antifungal combination of the drug
with the CH activity. All these results suggest that these polymeric films containing ECN are
potential candidates in view of alternatives dosages forms for the treatment of the yeast assayed.
greater as the commercial cream, probably as a result of the antifungal combination of the drug
with the CH activity. All these results suggest that these polymeric films containing ECN are
potential candidates in view of alternatives dosages forms for the treatment of the yeast assayed.
greater as the commercial cream, probably as a result of the antifungal combination of the drug
with the CH activity. All these results suggest that these polymeric films containing ECN are
potential candidates in view of alternatives dosages forms for the treatment of the yeast assayed.
greater as the commercial cream, probably as a result of the antifungal combination of the drug
with the CH activity. All these results suggest that these polymeric films containing ECN are
potential candidates in view of alternatives dosages forms for the treatment of the yeast assayed.
greater as the commercial cream, probably as a result of the antifungal combination of the drug
with the CH activity. All these results suggest that these polymeric films containing ECN are
potential candidates in view of alternatives dosages forms for the treatment of the yeast assayed.
greater as the commercial cream, probably as a result of the antifungal combination of the drug
with the CH activity. All these results suggest that these polymeric films containing ECN are
potential candidates in view of alternatives dosages forms for the treatment of the yeast assayed.
Candida krusei and Candida parapsilosis was twice as
greater as the commercial cream, probably as a result of the antifungal combination of the drug
with the CH activity. All these results suggest that these polymeric films containing ECN are
potential candidates in view of alternatives dosages forms for the treatment of the yeast assayed.