IQUIR 05412
INSTITUTO DE QUIMICA ROSARIO
Unidad Ejecutora - UE
artículos
Título:
Stereoselective, solid phase-based synthesis of trans 3-alkyl-substituted b-lactams as analogues of cholesterol absorption inhibitors
Autor/es:
DELPICCOLO, C. M. L.; TESTERO, S. A.; LEYES, F. N.; BOGGIÁN, D. B.; CAMACHO, C. M.; MATA, E. G.
Revista:
TETRAHEDRON
Editorial:
PERGAMON-ELSEVIER SCIENCE LTD
Referencias:
Lugar: Amsterdam; Año: 2012 vol. 68 p. 10780 - 10786
ISSN:
0040-4020
Resumen:
A straightforward solid phase-based strategy for the rapid generation of two small libraries of trans 3-alkyl-substituted beta-lactams is described. For the glycine-derived library, a controlled excess of nonactivated acid chlorides was used to prevent oxazinone formation. The second library involved the attachment of Fmoc-protected p-aminophenol to Wang resin for the preparation of structurally-closed analogues of known cholesterol absorption inhibitors. This strategy allowed us to introduce diversity in the three variable positions of the b-lactam ring.
