IQUIR 05412
INSTITUTO DE QUIMICA ROSARIO
Unidad Ejecutora - UE
artículos
Título:
Enantiocomplementary Access to Carba-Analogs of C-Nucleoside Derivatives by Recombinant Baeyer-Villiger Monooxygenases
Autor/es:
DARÍO A. BIANCHI; ROBERTO MORAN-RAMALLAL; NASEEM IQBAL; FLORIAN RUDROFF; MARKO D. MIHOVILOVIC
Revista:
BIORGANIC AND MEDICINAL CHEMISTRY LETTERS
Editorial:
Elsevier Ltd.
Referencias:
Año: 2013 p. 1 - 1
ISSN:
0960-894X
Resumen:
A novel and stereoselective synthetic route towards carba-C-nucleosides was investigated applying an enantiodivergent biooxidation strategy by two different Baeyer-Villiger monooxygenases. Within only three chemo-enzymatic steps it was possible to introduce four chiral centers starting from commercially available non-chiral starting material.
