IQUIR   05412
INSTITUTO DE QUIMICA ROSARIO
Unidad Ejecutora - UE
artículos
Título:
Chiral Auxiliary-Mediated Enantioenrichment of (±)-Ibuprofen, under Steglich conditions, with Secondary Alcohols derived from (R)-Carvone
Autor/es:
AMONGERO, M.; VISNOVEZKY, D.; KAUFMAN, T. S.
Revista:
JOURNAL BRAZILIAN CHEMISTRY SOCIETY
Editorial:
SBQ
Referencias:
Año: 2010 vol. 21 p. 1017 - 1036
ISSN:
1678-4790
Resumen:
The synthesis of a series of chiral secondary alcohols derived from (R)-carvone, and the stereochemical outcome of their reaction with (±)-ibuprofen, is reported. The racemic drug was transformed into the corresponding diastereomeric esters mediated by DCC/DMAP, affording up to 5.7:1 diastereomeric ratios of the esters derived from either (S)- or (R)-ibuprofen, depending on the type of chiral auxiliary employed.