IQUIR   05412
INSTITUTO DE QUIMICA ROSARIO
Unidad Ejecutora - UE
artículos
Título:
Influence of Water Uptake, Gel Network, and Disintegration Time on Prednisone Release from Encapsulated Solid Dispersions
Autor/es:
LEONARDI, D.; SALOMÓN, C. J.
Revista:
Pharmaceutical Development and Technology
Editorial:
Taylor & Francis
Referencias:
Lugar: New York; Año: 2010 vol. 15 p. 184 - 191
ISSN:
1083-7450
Resumen:
Prednisone is considered the glucocorticoid of choice for anti-inflammatory and immunosuppressant effects. However, its very low aqueous solubility can compromise oral bioavailability. Changes in the dissolution of a prednisone-PEG 6000 solid dispersion into capsule were investigated by addition of pregelatinized starch. Physical state of prednisone:PEG 6000 was analyzed by X-ray diffractometry, and scanning electron microscopy. Capsule formulations containing prednisone-PEG 6000 and pregelatinized starch showed superior dissolution properties (>95% in 60min) when compared with reference capsules without disintegrant (<45% in 60min). Water uptake and disintegration time were directly correlated with pregelatinized starch amount. The morphology of prednisone-PEG 6000 particles with disintegrant was analyzed by SEM, showing a novel surface structure. Thus, solid dispersions of a poorly water soluble drug combined with a disintegrant were confirmed as a valid approach to the improvement of drug dissolution.