An Economical and Convenient Carbonyl Transposition Approach Towards a 2-Arylcycloheptanone Derivative

ANDREA B. J. BRACCA; TEODORO S. KAUFMAN

SYNTHETIC COMMUNICATIONS

Taylor & Francis

Lugar: Estados Unidos; Año: 2006 vol. 36 p. 299 - 310

0039-7911

A convenient, straightforward, and easy access to 2(2,3-dimethoxy-phenyl)- cycloheptanone, which employs an heteroatom-facilitated ortho-lithiation coupled to a carbonyl transposition strategy, is reported. The synthetic approach avoids using very expensive reagents or difficult-to-prepare starting materials.ortho-lithiation coupled to a carbonyl transposition strategy, is reported. The synthetic approach avoids using very expensive reagents or difficult-to-prepare starting materials.