IQUIR 05412
INSTITUTO DE QUIMICA ROSARIO
Unidad Ejecutora - UE
artículos
Título:
Synthesis and Complement Inhibitory Activity of 3H-Spiro[benzofuran-2,1'-cyclohexanes] Derived from the naturally-occurring filifolinol
Autor/es:
MARIANA USEGLIO; PATRICIA M. CASTELLANO; MARÍA A. OPERTO; RENÉ TORRES; TEODORO SAUL KAUFMAN
Revista:
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Editorial:
Elsevier
Referencias:
Lugar: Holanda; Año: 2006 vol. 16 p. 5097 - 5101
ISSN:
0960-894X
Resumen:
Six 3H-spiro[benzofuran-2,10-cyclohexane] derivatives were synthesized from naturally occurring filifolinol, and their classical complement pathway inhibitory activity was determined. IC50 values of the most potent compounds were comparable to the activity of the natural complement inhibitor K76-COOH and some synthetic tricyclic analogs of it.
