Synthesis, characterization and biological studies of a cobalt(III) complex of sulfathiazole

FERESIN, GABRIELA EGLY; WILLIAMS, PATRICIA A.M.; MOSCONI, NATALIA; NERLI, BIBIANA; NERLI, BIBIANA; RAIMONDI, MARCELA; RAIMONDI, MARCELA; MONTI, LAURA; MONTI, LAURA; RIZZOTTO, MARCELA; RIZZOTTO, MARCELA; LIMA, BEATRIZ; LIMA, BEATRIZ; BELLÚ, SEBASTIÁN; BELLÚ, SEBASTIÁN; PONTORIERO, ANA; PONTORIERO, ANA; FERESIN, GABRIELA EGLY; WILLIAMS, PATRICIA A.M.; MOSCONI, NATALIA

CHEMICO-BIOLOGICAL INTERACTIONS

ELSEVIER IRELAND LTD

Lugar: Amsterdam; Año: 2017 vol. 278 p. 152 - 161

0009-2797

The emergence of old and new antibiotic resistance created in the last decades revealed a substantial medicalneed for new classes of antimicrobial agents. The antimicrobial activity of sulfa drugs is often enhanced bycomplexation with metal ions, which is in concordance with the well-known importance of metal ions in biologicalsystems. Besides, sulfonamides and its derivatives constitute an important class of drugs, with severaltypes of pharmacological agents possessing antibacterial, anti-carbonic anhydrase, diuretic, hypoglycemic, antithyroid,antiviral and anticancer activities, among others.The purpose of this work has been the obtainment, characterization and determination of biological properties(antibacterial, antifungal, mutagenicity and phytotoxicity) of a new Co(III)-sulfathiazole complex: Costz,besides of its interaction with bovine serum albumin (BSA). The reaction between sodium sulfathiazole (Nastz)and cobalt(II) chloride in the presence of H2O2 leads to a brown solid, [CoIII(stz)2OH(H2O)3], (Costz). Thestructure of this compound has been examined by means of elemental analyses, FT-IR, 1H NMR, UV?Visiblespectrometric methods and thermal studies. The Co(III) ion, which exhibits a distorted octahedral environment,could coordinate with the N thiazolic atom of sulfathiazolate. The complex quenched partially the nativefluorescence of bovine serum albumin (BSA), suggesting a specific interaction with the protein. The Costzcomplex showed, in vitro, a moderate antifungal activity against Aspergillus fumigatus and A. flavus. As antibacterial,Costz displayed, in vitro, enhanced activity respective to the ligand against Pseudomonas aeruginosa.Costz did not show mutagenic properties with the Ames test. In the Allium cepa test the complex showed cytotoxicproperties but not genotoxic ones. These results may be auspicious, however, further biological studiesare needed to consider the complex Costz as a possible drug in the future.