INTEC   05402
INSTITUTO DE DESARROLLO TECNOLOGICO PARA LA INDUSTRIA QUIMICA
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Hyaluronic acid microgels prepared by a microfluidic approach for the delivery of hydrophobic drugs
Autor/es:
VALÉRIE RAVAINE; DIANA ESTENOZ; CARLOS BUSATTO
Reunión:
Simposio; Virtual International Symposium on Nano/Microgels; 2020
Institución organizadora:
Basque Center for Macromolecular Design and Engineering (POLYMAT) - Universidad Nacional de Córdoba
Resumen:
HA-based microgels for the encapsulation and enzymatic-triggered release of progesterone were prepared using a microfluidic approach (Figure 1a). Microgel synthesis involved the following steps: (i) generation of a primary oil/water (O/W) nanoemulsion by the ultrasonication method, (ii) formation of a double oil/water/oil (O/W/O) emulsion using a ?co-flow? microfluidic device, and (iii) crosslinking of microdroplets by photopolymerization of the modified HA precursors with methacrylate groups (AH-MA) present in the aqueous phase. This approach allowed the incorporation of an oil nanoemulsion containing the drug inside hydrophilic microgels through the formation of a double O/W/O emulsion, where the aqueous phase subsequently becomes the gel phase. Microfluidics offered a precise control for the formation of a double emulsion and allowed on-line photopolymerization of microgels. The enzymatic degradation of the microgels was used to provoke the release of the progesterone-loaded oil nano-drops.