Novel Enteric Coating Based on Acrylic/casein Dispersions for Smart Delivery Systems

PICCHIO, MATÍAS L.; PASSEGGI, MARIO C. G.; ALVAREZ IGARZABAL, CECILIA I.; PALMA, SANTIAGO D.; MINARI, ROQUE J.; PAREDES, ALEJANDRO J.; GUGLIOTTA, LUIS M.

Bahía Blanca

Workshop; III Workshop de Polímeros Biodegradables y Biocompatibles, Biopoli 2018; 2018

Universidad de Bahía Blanca - Plapiqui

Over the past few years, increasing attention for the design of new drug delivery systems based on milk proteins has been drawn due to their excellent functional properties. In this study, we report a new approach for preparing protein-based film coating using highly methacrylated casein as a macro-crosslinker. Films exhibited a smooth surface with an even casein distribution as evidenced by both SEM and AFM. The mechanical behavior of the casein-based films could be easily tuned by controlling the methacrylation degree of the bio-based cross-linker. The as-prepared films showed pH-dependence swelling, in which swelling ability in alkaline medium was stronger than that at acid pH. The mechanical, swelling, rheological and release performance of the casein-based films suggest that these materials have a high potential as enteric coatings for intestine drug delivery.