An alternative for the treatmant of Chagas disease: hydrogels for Benznidazol controlled release

GONZALEZ VERONICA; GARCIA VALERIA; GUGLIOTTA LUIS

Cancún

Congreso; XV Simposio Latinoamericano de Polímeros ? XIII Congreso Iberoamericano de Polímeros; 2016

Chagas? disease is an illnes that affects 8 to 10 million people. Benznidazole (Bz) is the drug most widely used drug for treating Chagas. Between 4% and 20% of adult patients treated with Bz have shown side effects. Here we propose the use of patches formed from hydrogels for Bz controlled release. The use of hydrogels to this purpose not only allows the controlled drug administration, but also reduces the frequency and magnitude of Bz dose; which reduces the occurrence of side effects and increases comfort in the administration. In the present work, the following variables were studied in order to find the best conditions for the release of Bz from N,N-dimethylacrylamide (DMA) hydrogels: i) the release time; ii) the hydrogel thickness (5 and 1 mm); iii) the strategy the Bz load (during the synthesis and after synthesis); and iv) the release medium (pH 5 and pH 7).