INTEC   05402
INSTITUTO DE DESARROLLO TECNOLOGICO PARA LA INDUSTRIA QUIMICA
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Chitosan microparticles containing Sodium Fluoride prepared by fluidized bed technology
Autor/es:
DR. JULIO A. LUNA; FEDERICO FOOKES
Lugar:
Rosario
Reunión:
Congreso; 4ta. Reunión Internacional de Ciencias Farmacéuticas- RICiFA; 2016
Institución organizadora:
Lab. Qca. Fina.- INTEC - UNL - CONICET
Resumen:
Sodium Fluoride (NaF) is used in the treatment of osteoporosis due to it stimulates the formation of bone tissue by replacing the Hydroxylapatite's hydroxyl group. Chitosan extends the residence time in the gastro-intestinal tract and increase drug absorption. The aim of this work is to develop chitosan microparticles for fluoride controlled release intended for osteoporosis treatment. Particles will be prepared using fluidized bed technology and characterized by studying drug's release profiles, size distribution, interaction between the system components and process variables. Microparticles were manufactured in a fluidized bed with chitosan particles as a core following two strategies: (i) by using chitosan as received, (ii) using chitosan particles separated into three size populations (0-75µm, 75 - 177 µm and 177 - 297 µm). In both strategies particles were fluidized and sprayed with a 1 % wt NaF solution. Furthermore, particles sized between 177-297µm were coated with a 10 wt % polyvinylpyrrolidone (pvp) solution. Particle size distribution was studied by sieving and image analyzing software. Particles were characterized by Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM). Drug release was analyzed in a phosphate-buffered saline media (37ºC, 100 r.p.m.). Smallest particles population (0 - 75 µm) showed an overwetting effect. FTIR studies show the presence of chitosan and pvp in the particles. SEM images shows that NaF is deposited as crystals (2 µm approx.) onto the surface of the particles while pvp form a dispersion but not a continuous layer. The release profile of every developed particle showed a burst effect. Chitosan-NaF microparticles were made using fluidized bed technology varying the composition and process condition. Characterizations were made by studying the release profiles, size distribution and interactions between the components of the systems. Particles showed an initial burst effect which should be diminished in further research.