INTEC   05402
INSTITUTO DE DESARROLLO TECNOLOGICO PARA LA INDUSTRIA QUIMICA
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Microfluidic-based Preparation of Hyaluronic Acid Microgels for Progesterone Delivery
Autor/es:
HÉLÈNE LABIE; RACHEL AUZÉLY-VELTY; VALÉRIE RAVAINE; CARLOS BUSATTO; ADELINE PERRO-MARRE; DIANA ESTENOZ; VÉRONIQUE LAPEYRE; NATALIA CASIS
Lugar:
Foz do Iguaçu
Reunión:
Congreso; 9º Congreso Latinoamericano de Órganos Artificiales y Biomateriales (COLAOB); 2016
Resumen:
Progesterone delivery systems have been proposed for regulating the estrous cycle in cattle by incorporating progesterone into biodegradable and non-biodegradable polymeric matrices. In recent years, polymer microgels have received considerable attention due to their great potential in the biomedical field as drug delivery systems. Hyaluronic acid (HA) is a naturally occurring glycosaminoglycan that can be cleaved by hyaluronidase present in vivo. The objective of this work is to preparate biodegradable HA microgels by a co-flow microfluidic strategy for the encapsulation and controlled release of progesterone. The approach relies on (i) the generation of a primary organic/water (O/W) nanoemulsion, (ii) microfluidic emulsification of the primary emulsion, and (iii) photopolymerization of HA precursors with polymerizable methacrylate groups (HA-MA) present in the aqueous phase of the droplets. The potential use for progesterone delivery applications was evaluated through degradability and encapsulation/release studies in presence of hyaluronidase.