INTEC 05402
INSTITUTO DE DESARROLLO TECNOLOGICO PARA LA INDUSTRIA QUIMICA
Unidad Ejecutora - UE
artículos
Título:
Characterization of SARS-CoV-2 Dynamics in the Host
Autor/es:
PABLO ABUIN; ESTEBAN HERNANDEZ-VARGAS; ANDERSON, ALEJANDRO; GONZÁLEZ, ALEJANDRO H.; FERRAMOSCA, ANTONIO
Revista:
ANNUAL REVIEWS IN CONTROL
Editorial:
PERGAMON-ELSEVIER SCIENCE LTD
Referencias:
Lugar: Amsterdam; Año: 2020 vol. 50 p. 457 - 468
ISSN:
1367-5788
Resumen:
While many epidemiological models were proposed to understand and handle COVID-19, too little has been invested to understand human viral replication and the potential use of novel antivirals to tackle the infection. In this work, using a control theoretical approach, validated mathematical models of SARS-CoV-2 in humans are characterized. A complete analysis of the main dynamic characteristic is developed based on the reproduction number. The equilibrium regions of the system are fully characterized, and the stability of such regions are formally established. Mathematical analysis highlights critical conditions to decrease monotonically SARS-CoV-2 in the host, as such conditions are relevant to tailor future antiviral treatments. Simulation results validates the aforementioned system characterization.
