INTEC   05402
INSTITUTO DE DESARROLLO TECNOLOGICO PARA LA INDUSTRIA QUIMICA
Unidad Ejecutora - UE
artículos
Título:
Comprehensive model of electromigrative transport in microfluidic paper based analytical devices
Autor/es:
BERLI, CLAUDIO L. A.; BERLI, CLAUDIO L. A.; SCHAUMBURG, FEDERICO; SCHAUMBURG, FEDERICO; KLER, PABLO A.; KLER, PABLO A.
Revista:
ELECTROPHORESIS
Editorial:
WILEY-V C H VERLAG GMBH
Referencias:
Año: 2020 p. 598 - 606
ISSN:
0173-0835
Resumen:
A complete mathematical model for electromigration in paper‐based analytical devices is derived, based on differential equations describing the motion of fluids by pressure sources and EOF, the transport of charged chemical species, and the electric potential distribution. The porous medium created by the cellulose fibers is considered like a network of tortuous capillaries and represented by macroscopic parameters following an effective medium approach. The equations are obtained starting from their open‐channel counterparts, applying scaling laws and, where necessary, including additional terms. With this approach, effective parameters are derived, describing diffusion, mobility, and conductivity for porous media. While the foundations of these phenomena can be found in previous reports, here, all the contributions are analyzed systematically and provided in a comprehensive way. Moreover, a novel electrophoretically driven dispersive transport mechanism in porous materials is proposed. Results of the numerical implementation of the mathematical model are compared with experimental data, showing good agreement and supporting the validity of the proposed model. Finally, the model succeeds in simulating a challenging case of free‐flow electrophoresis in paper, involving capillary flow and electrophoretic transport developed in a 2D geometry.