INTEC   05402
INSTITUTO DE DESARROLLO TECNOLOGICO PARA LA INDUSTRIA QUIMICA
Unidad Ejecutora - UE
artículos
Título:
Accurate prediction of shape and size of polyvinyl alcohol beads produced by extrusion dripping
Autor/es:
WEIBEL, MARIO IGNACIO; RINTOUL, IGNACIO; MENGATTO, LUCIANO NICOLÁS; LUNA, JULIO ALBERTO
Revista:
IRANIAN POLYMER JOURNAL
Editorial:
POLYMER RESEARCH CENTER IRAN
Referencias:
Lugar: Berlin; Año: 2018 vol. 27 p. 161 - 170
ISSN:
1026-1265
Resumen:
p { margin-bottom: 0.25cm; line-height: 120%; }Beads are one of theparticulate delivery systems used to achieve protection and/orcontrolled delivery of different active ingredients ormicroorganisms. Polyvinyl alcohol is a non-toxic and biodegradablepolymer and possesses extensive applications as a biomaterial. In thepresent work, two different strategies were applied for theprediction of shape and size of polyvinyl alcohol beads. These beadswere obtained by extrusion dripping of a boric acid?polyvinylalcohol aqueous solution into a basic aqueous gelling bath. Theshapes and sizes of immature, mature and dry beads were determinedusing optical microscopy. Two different strategies includedstatistical and fluid dynamical (mechanistic) models to fit theexperimental data. The shape of immature and mature beads was foundto be dependent on the viscosity of the dripping solution for theformer and the maturation time for the latter. The shape of dry beadswas found to be mainly dependent on the particle contraction in thedrying process. The size of mature and dried beads was correctlypredicted from the operating conditions by means of a statisticallydeveloped model and from the dripping solution properties by means ofa fluid dynamical approach. The optimal conditions for minimal driedbead size were calculated. The obtained mathematical models allowreduction in the amount of resources and time taken in the initialstages of the development of a novel encapsulated formulation. Themechanistic model may be applied to other polymeric systems once thecorresponding parameters have been determined during proof-of-conceptexperiments.