INTEC   05402
INSTITUTO DE DESARROLLO TECNOLOGICO PARA LA INDUSTRIA QUIMICA
Unidad Ejecutora - UE
artículos
Título:
PLGA nano- and microparticles for the controlled release of florfenicol: Experimental and theoretical study
Autor/es:
KARP, F.; LUNA, J. A.; BUSATTO, C. A.; ESTENOZ, D. A.; TURINO, L. N.
Revista:
JOURNAL OF APPLIED POLYMER SCIENCE
Editorial:
JOHN WILEY & SONS INC
Referencias:
Año: 2018 p. 47248 - 47257
ISSN:
0021-8995
Resumen:
In this study, PLGA particle systems were studied for the controlled release of florfenicol, a broad spectrum antibiotic usedin veterinary treatments. The emulsion-solvent evaporation technique was used for particle preparation. To evaluate the particle size,entrapment efficiency, and drug release behavior, factors such as solvent type, emulsification time and methods, and drug to polymerratio were investigated. The results showed that the use of ethyl acetate and 2.5 min of ultrasonication or 30 min of homogenization canlead to sub-micron and micron-sized particles, respectively. Sizes between 200?300 nm and 2?3 μm were obtained for ultrasonicationand homogenization procedures, respectively. Entrapment efficiencies were around 20% for all systems and release profiles were sizedependent. In addition, a mathematical model was implemented to simulate the florfenicol transport. The model predicts the florfenicolrelease and takes into account the particle size, polymer molecular weight, and autocatalytic polymer degradation. Simulation results arein good agreement with experimental results.