INTEC   05402
INSTITUTO DE DESARROLLO TECNOLOGICO PARA LA INDUSTRIA QUIMICA
Unidad Ejecutora - UE
artículos
Título:
Paclitaxel delivery system based on poly(lactide-co-glycolide) microparticles and chitosan thermo-sensitive gel for mammary adenocarcinoma treatment
Autor/es:
PESOA, JUAN I.; SCHAROVSKY, O. GRACIELA; RICO, MARÍA J.; LUNA, JULIO A.; ROZADOS, VIVIANA R.; MENGATTO, LUCIANO N.
Revista:
JOURNAL OF PHARMACY AND PHARMACOLOGY
Editorial:
PHARMACEUTICAL PRESS-ROYAL PHARMACEUTICAL SOC GREAT BRITIAN
Referencias:
Año: 2018
ISSN:
0022-3573
Resumen:
Objectives To evaluate the combination of more than one release system in thesame formulation as a useful strategy to achieve paclitaxel delivery in a more sustained and controlled manner.Methods The present study deals with the preparation of poly(lactide-co-glycolide) microparticles loaded with paclitaxel and included in a chitosan thermosensitive gelling solution. The microparticles were characterized by their size, shape and drug loading. The formulation was characterized by scanning electron microscopy, in vitro release experiments and was evaluated in mice bearing mammary adenocarcinoma.Key findings The formation of paclitaxel crystals in a pharmaceutical formulation reduces its efficacy. In this work, the use of microparticles avoided this phenomenon. Combining more than one delivery system allowed delivering paclitaxel in a more sustained and controlled manner leading to a long-term effect in the site of action. The formulation showed an inhibition in tumour volume of 63.0% in comparison with the control group.Conclusions One intratumour injection of gelling solution containing the microparticles was at least as efficacious as four intraperitoneal injections of a commercial formulation. In addition, the delivery system was nontoxic, and the treated mice presented the highest percentage of tumour regression and median survival time.