Controlled fluoride release for osteoporosis treatment using orally administered chitosan hydrogels

FEDERICO FOOKES; LUCIANO MENGATTO,; DR. JULIO A. LUNA

ELSEVIER SCIENCE B. V.

Journal of Drug Delivery Science and Technology

Año: 2018

Chitosan - β-glycerophosphate hydrogels have been widely studied for biomedical applications in recent years.In the current study a Chitosan - β-glycerophosphate hydrogel was evaluated as a platform for sodium fluoriderelease in the gastrointestinal tract. For this purpose, microscopy observation, infrared spectroscopy, stability,rheology studies and in vitro release assays were carried out. The hydrogel was stable for at least 48 h whenexposed to an aqueous media in a pH range from 4 to 7 and the release of sodium fluoride was controlled formore than 6 h.In vivo studies were carried out in order to evaluate the oral administration of sodium fluoride using thehydrogel in comparison to a water solution. Fluoride pharmacokinetic was similar when the drug was administeredwith both formulations. Nevertheless, fluoride absorption was greater when the drug was given withthe hydrogel, and further, drug-related side effects were absents. These results suggest that Chitosan - β-glycerophosphatehydrogel could be a good candidate for sustained release of fluoride in oral formulation.