INTEC   05402
INSTITUTO DE DESARROLLO TECNOLOGICO PARA LA INDUSTRIA QUIMICA
Unidad Ejecutora - UE
artículos
Título:
“Influence of Cross-Linking Density on Swelling and Estradiol Permeation of Chitosan Membranes”
Autor/es:
LUCIANO N. MENGATTO; JULIO A. LUNA; MARÍA I. CABRERA
Revista:
Journal of Materials Science
Editorial:
Springer
Referencias:
Lugar: Tamilnadu, India; Año: 2010 vol. 45 p. 1046 - 1051
ISSN:
0022-2461
Resumen:
Chitosan membranes were obtained by a casting/solvent evaporation method and crosslinking with sodium tripolyphosphate. The effect of cross-linking time was studied and the cross-linked membranes were characterized with respect to equilibrium water content, sodium content and permeability to a model drug (Estradiol). Sodium content increased with increasing cross-linking time.Equilibrium water content was higher in the membrane with the lowest cross-linking time. This membrane also showed a higher flux of Estradiol compared with the other which exhibited an increment in equilibrium water content and flux of Estradiol with the increase in cross-linking duration. These dissimilar results could be explained by an altered type of linkage between chitosan and the cross-linking agent or by a significant correlation between the hydrophilicity of the membrane and the hydrophobicity of Estradiol.